Hypoglycemic, hypolipidemic and body weight effects of unripe pulp of Carica papaya using diabetic Albino rat model.

Abstract

The present study was designed to evaluate some selected biochemical effects of unripe pulp of Carica papaya on alloxan induced diabetes in rats. Animals weighing (160-200 g) were divided into three (3) groups of 10 animals each; Group I (normal control), Group II (diabetic control) and Group III (test control). Diabetes was induced in albino rats by intraperitoneal injection of alloxan monohydrate at a single dose of 120 mg/kg body weight into groups II and III respectively. Animals in groups I and II received normal rat feeds while animals in group III were fed with unripe pulp of Carica papaya for a period of 28 days. Body weight and glucose levels were measured on days 0, 7, 14, 21, and day 28. It was observed in this study that there was a significant reduction of Glycated hemoglobin in the test group when compared with the induced control (diabetic rats) and normal control group (P