Ameliorative potential of aqueous leaves extract of Syzygium cumini (L) associated metabolic alterations in Alloxan induced diabetic rats

Abstract

In the present study oral administration of aqueous extract of Syzygium cumini to Alloxan monohydrate induced diabetic rats secluded the rats from the changes induced in carbohydrate and lipid metabolism. The increase in the glycosylated hemoglobin is a sign of succession in diabetes. In addition during diabetes there is an enhancement in the cholesterol and triglyceride contents. The Supplementation of Syzygium cumini leaves aqueous extract (200 mg/kg bw) brought the levels of glucose (98±8.4) and lipids (LDL: 32.14±2.71 b and VLDL: 25.71±1.86 b) to almost normal by demonstrating anti-hypoglycemic and anti-lipidemic properties. The reduction in HDL cholesterol in diabetic rats can be used as a marker in the evaluating the severity of diabetes.