Identification of glucosidases inhibitory potential from Citrullus lanatus seed extract

Abstract

The aim of the study was to evaluate the I±-amylase and I±-glucosidase inhibitory potential of Citrullus lanatus seed methanol extract in regulating postprandial hyperglycemia. In vitro I±-amylase and I±-glucosidase inhibition assay was performed by standard protocols using the extract at ten different concentrations. The methanolic extract of C. lanatus exhibited the best inhibitory activity against I±-glucosidase with IC50 values of 54.44 I¼g/ml and a mild inhibitory activity against I±-amylase with IC50 values of 76.68 I¼g/ml. Hence, from the present study, we conclude that C. lanatus seed methanol extract is a potent glucosidase inhibitor which can be used in the management of type 2 diabetes.