In-Vitro Cytotoxic and Thrombolytic Potential of Pothos scandens L

Abstract

The methanolic extract of leaf of Pothos scandens was subjected to screening for cytotoxic activity by in-vitro brine shrimp lethality bioassay and thrombolytic activity. In brine shrimp bioassay, the crude methanolic extract of leaf showed strong cytotoxic activity with LC50 value of 14.195I¼g/ml compared to that of 0.305I¼g/ml exhibited by standard vincristine sulphate. During assay for thrombolytic activity, the methanolic extract of P. scandens revealed 19.451±1.711% lysis of clot while standard streptokinase (SK) and water, used as positive and negative controls, demonstrated 69.480± 2.651% and 3.0695± 0.497% lysis of clot, respectively.