article Open AccessTop 1% cited
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Genome biology · 2016 · Vol. 17(1) · pp. 208–208
Ruth Pidsley✉(Garvan Institute of Medical Research)Elena Zotenko(Garvan Institute of Medical Research)Timothy J. Peters(Garvan Institute of Medical Research)Mitchell G. Lawrence(Monash University)Gail P. Risbridger(Monash University)Peter L. Molloy(CSIRO Health and Biosecurity)Susan Van Djik(CSIRO Health and Biosecurity)Beverly S. Mühlhäusler(South Australian Health and Medical Research Institute)Clare Stirzaker(St Vincent's Clinic)Susan J. Clark(St Vincent's Clinic)
Abstract
The EPIC array is a significant improvement over the HM450 array, with increased genome coverage of regulatory regions and high reproducibility and reliability, providing a valuable tool for high-throughput human methylome analyses from diverse clinical samples.
Epigenetics and DNA MethylationGenomics and Chromatin DynamicsRNA modifications and cancerBiologyDNA methylationGenomeComputational biologyHuman geneticsMicroarrayGeneticsEpigeneticsDNA microarrayWhole genome sequencing
MeSH terms
Enhancer Elements, GeneticHumansGenome, HumanSequence Analysis, DNACpG IslandsDNA MethylationOligonucleotide Array Sequence AnalysisHigh-Throughput Nucleotide Sequencing
Funding
- Prostate Cancer Foundation
- Science and Industry Endowment Fund
- Movember Foundation
- Australian Prostate Cancer Research
- Prostate Cancer Foundation of Australia
- National Breast Cancer Foundation
- Cancer Australia
- Medical Research Council
- National Health and Medical Research Council
Citations
1,592
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38.82
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43
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