review Open AccessTop 10% cited
Biologically active γ-lactams: synthesis and natural sources
Organic & Biomolecular Chemistry · 2016 · Vol. 14(43) · pp. 10134–10156
Joséphine Caruano(UCLouvain)Giulio G. Muccioli(UCLouvain)Raphaël Robiette✉(Institut des Arts de Diffusion)
Abstract
The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.
Synthesis and Biological ActivitySynthesis of β-Lactam CompoundsMicrobial Natural Products and BiosynthesisChemistryMoietyBiological activityNatural (archaeology)Combinatorial chemistryLactamNatural compoundStereochemistryBiochemical engineeringBiochemistry
MeSH terms
AlkylationAnti-Bacterial AgentsBiological ProductsCyclizationLactamsChemistry Techniques, Synthetic
Citations
402
FWCI
10.47
field-weighted impact
References
180
Percentile
99%
vs. same field & year
Citations per year
References
Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme
Applied and Environmental Microbiology · 1988 · 1,264 citations
Discovery and development of the anticancer agent salinosporamide A (NPI-0052)
Bioorganic & Medicinal Chemistry · 2008 · 284 citations
Total Synthesis and Biological Activity of Lactacystin, Omuralide and Analogs.
Chemical and Pharmaceutical Bulletin · 1999 · 190 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.