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Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
Cell stem cell · 2016 · Vol. 19(2) · pp. 248–257
Junghyun Jo(Genome Institute of Singapore)Yixin Xiao(National University of Singapore)Alfred Xuyang Sun(National Neuroscience Institute)Engin Cukuroglu(Genome Institute of Singapore)Hoang-Dai Tran(National University of Singapore)Jonathan Göke(Genome Institute of Singapore)Zi Ying Tan(National University of Singapore)Tzuen Yih Saw(Genome Institute of Singapore)Cheng-Peow Tan(Genome Institute of Singapore)Hidayat Lokman(Duke-NUS Medical School)Younghwan Lee(Duke-NUS Medical School)Donghoon Kim(Johns Hopkins University)Han Seok Ko(Johns Hopkins University)Seong‐Oh Kim(Nanyang Technological University)Jae Hyeon Park(Nanyang Technological University)Nam‐Joon Cho(Nanyang Technological University)Thomas M. Hyde(Johns Hopkins University)Joel E. Kleinman(Johns Hopkins University)Joo Heon Shin(Lieber Institute for Brain Development)Daniel R. Weinberger(Johns Hopkins University)Eng‐King Tan(National Neuroscience Institute)H. Shawn Je✉(National University of Singapore)Huck‐Hui Ng✉(National University of Singapore)
Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomicsOrganoidMidbrainNeuromelaninBiologyInduced pluripotent stem cellSubstantia nigraCell biologyDopaminergicEmbryonic stem cellNeuroscience
MeSH terms
Cell DifferentiationCell LineHumansMelaninsMesencephalonOrganoidsTranscription, GeneticPluripotent Stem CellsDopaminergic Neurons
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Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
Cell Reports · 2012 · 649 citations
Software for Computing and Annotating Genomic Ranges
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Genome biology · 2013 · 13,586 citations
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Genome biology · 2014 · 97,164 citations
Organoids as an in vitro model of human development and disease
Nature Cell Biology · 2016 · 1,459 citations
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