article Open AccessTop 1% cited

Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography

Investigative Ophthalmology & Visual Science · 2016 · Vol. 57(9) · pp. OCT362–OCT362

Alice Y. Kim(Southern California Eye Institute)Zhongdi Chu(University of Washington)Anoush Shahidzadeh(University of Southern California)Ruikang K. Wang(University of Washington)Carmen A. Puliafito(University of Southern California)Amir H. Kashani✉(Southern California Eye Institute)

View via DOI Full-text PDF

Abstract

Vascular changes in DR can be objectively and reliably characterized with SD, VD, FD, and VDI. In general, decreasing capillary density (SD and VD), branching complexity (FD), and increasing average vascular caliber (VDI) were associated with worsening DR. Changes in capillary density and morphology were significantly correlated with diabetic macular edema.

Retinal Imaging and Analysis Retinal Diseases and Treatments Glaucoma and retinal disordersDiabetic retinopathyRetinalOphthalmologyMedicineRepeatabilityOptical coherence tomography angiographyOptical coherence tomographyMicroangiographyNuclear medicineReproducibility

MeSH terms

AdultAgedAlgorithmsCapillariesCross-Sectional StudiesDiabetic RetinopathyFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMacular EdemaMaleMiddle AgedRetinal Vessels