Anti-Diabetic Activities of Aqueous Extract from Actinidia kolomikta Root Against α-glucosidase

Abstract

ABSTRACT The present study was to evaluate the anti-diabetic activity of the aqueous extract of Actinidia kolomikta root against baker's yeast α-glucosidase and rat intestinal α-glucosidase. As a result, the aqueous extract of Actinidia kolomikta root exhibited excellent baker's yeast α-glucosidase inhibitory activity which was better than acarbose. It also showed rat intestinal α-glucosidase inhibitory activity not only in maltase, but also in sucrase in a dose dependent manner. With these results, it can be concluded that Actinidia kolomikta root existed the anti-diabetic activity depend on their inhibitory activity on glucose absorption in the small intestine. The results also give scientific support to the utilization of Actinidia kolomikta root as folklore medicine for the treatment of diabetes. Keywords: Actinidia kolomikta , Anti-diabetic activity, α-Glucosidase 1. Introduction Diabetes mellitus is a global health problem and the diabetic was constantly increasing. The number of diabetic people is expected to rise to 366 million in 2030