Phytochemical and Pharmacological Assessment of the Ethanol Leaves Extract of Heritiera fomes Buch. Ham. (Family- Sterculiaceae)

Abstract

Purpose: The current study was themed to phytochemical and pharmacological investigation to determine anti-nociceptive, antioxidant and analgesic activity to give an appropriate guide for future exploration. Methods: Standard test methods were used to explore phytochemical constituents. The acetic acid-induced writhing model was applied to inspect chemical anti-nociceptive effect while thermal nociception was evaluated by hot plate model. DPPH assay was the choice of method for quantitative determination of antioxidant activity. Antimicrobial activity was assessed by disc diffusion assay method. Results: Phytochemical exploration of leaves extract demonstrated the presence of Reducing sugars, Saponins, alkaloids, glycosides, tannins, steroids, Flavonoids and Gums. The extract illustrated statistically significant anti-nociceptive activity (P