article Open AccessTop 1% cited
A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis
Cell stem cell · 2016 · Vol. 18(6) · pp. 827–838
Masayuki Fujii(Keio University)Mariko Shimokawa(Keio University)Shoichi Date(Otsuka (Japan))Ai Takano(Keio University)Mami Matano(Keio University)Kosaku Nanki(Keio University)Yuki Ohta(Keio University)Kohta Toshimitsu(Keio University)Yoshihiro Nakazato(Keio University)Kenta Kawasaki(Keio University)Toshio Uraoka(Keio University)Toshiaki Watanabe(The University of Tokyo)Takanori Kanai∥(Keio University)Toshiro Sato✉(Keio University)
Cancer Cells and MetastasisCancer Genomics and DiagnosticsGenetic factors in colorectal cancerOrganoidBiologyCarcinogenesisColorectal cancerCancer researchNichePhenotypeMetastasisMutationGene
MeSH terms
AnimalsEpidermal Growth FactorHumansMaleMutationOrganoidsTransplantation, HeterologousTumor Cells, CulturedColorectal NeoplasmsGenome, HumanGene Expression Regulation, NeoplasticTransforming Growth Factor betaMice, SCIDMice, Inbred NODGenetic Heterogeneity
Funding
- City University of Hong Kong
- Japan Agency for Medical Research and Development
- Research Center Network for Realization of Regenerative Medicine
Citations
836
FWCI
29.00
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
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Gastroenterology · 2011 · 3,707 citations
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Nature reviews. Cancer · 2009 · 2,612 citations
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Nature Genetics · 2002 · 2,483 citations
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Cell · 2011 · 65,668 citations
Comprehensive molecular characterization of human colon and rectal cancer
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