Resolvins, A powerful resolution mediator: Review

Abstract

Resolvins are endogenous lipid derived mediators generated by the host to regulate resolution of inflammation. They are biosynthesized from dietary fatty acid specifically omega 3 fatty acids. There are two major types of resolvins, E series and D series resolvins. Resolvins control the duration and magnitude of inflammation. They act as anti-inflammatory and proresolution mediators and decrease the tissue accumulation of neutrophils. As resolvins regulate recruitment of neutrophils and macrophages to the inflamed site, they show protective effect in inflammatory diseases like colitis, acute lung inflammation, periodontitis etc. Experiments in animals and humans suggest a new approach for the control of inflammation in these diseases without compromising the host defense.