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Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

Molecular Pharmacology · 1993 · Vol. 44(4) · pp. 707–715
Eicosanoids and Hypertension PharmacologyPharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and ProtectionEpoxide hydrolaseCYP1A2CYP3ACYP2E1Cytochrome P450CytokineTumor necrosis factor alphaBiologyInterleukinEpoxide hydrolase 2

MeSH terms

AdultAgedCells, CulturedCytochrome P-450 Enzyme SystemDepression, ChemicalEpoxide HydrolasesFemaleHumansInterferon-gammaInterleukin-1LiverMaleMiddle AgedModels, BiologicalRecombinant Proteins
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Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. · Scinovex