Lactic Dehydrogenase Activity in Blood.

Abstract

1. Lactic dehydrogenase activity is present in the venous serum of normal human adults. Normal activity ranges from 260 to 850 units per ml with a mean value of470 ± 130 units per ml. 2. Venous whole blood hemolysates of normal adults have a lactic dehydrogenase activity varying between 16,000 to 67,000 units per ml with a mean value of 34,000 ± 12,000 units per ml. 3. Alterations in serum lactic dehydrogenase have been studied in a selected group of disease states. 4. Experimental and clinical myocardial infarction are associated with a rise in serum lactic dehydrogenase activity. 5. Lactic dehydrogenase like serum glutamic oxaloacetic transaminase rises in a characteristic fashion following myocardial infarction.