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Organosilicon Molecules with Medicinal Applications
Journal of Medicinal Chemistry · 2012 · Vol. 56(2) · pp. 388–405
Annaliese K. Franz✉(University of California, Davis)Sean O. Wilson(University of California, Davis)
Abstract
The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.
Fluorine in Organic ChemistryCarbohydrate Chemistry and SynthesisChemical Synthesis and AnalysisOrganosiliconChemistrySmall moleculeMoleculeDrug discoveryCombinatorial chemistryNanotechnologyDrugOrganic chemistryPharmacology
MeSH terms
Amino AcidsDrug StabilityHydrogen BondingOrganosilicon Compounds
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References
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
Journal of Medicinal Chemistry · 2011 · 2,726 citations
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