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Inhibitors of xanthine oxidase from the flowers and buds of Daphne genkwa.
Chemical and Pharmaceutical Bulletin · 1983 · Vol. 31(11) · pp. 3984–3987
Abstract
Xanthine oxidase (XO) inhibitors were isolated from the flowers and buds of Daphne genkwa SIEB. et ZUCC. (Thymelaeaceae) and were identified as genkwanin (1), apigenin (2), luteolin 7-methyl ether (3) and luteolin (4). Compounds 2 and 4 showed particularly strong inhibitory activity against XO. The modes of inhibition by 2 and 4 with respect to xanthine as a substrate were of mixed type. This is the first report of isolation of 3 and 4 from these flowers and buds.
Bioactive Natural Diterpenoids ResearchTraditional and Medicinal Uses of AnnonaceaePhytochemistry and Bioactive CompoundsThymelaeaceaeXanthine oxidaseChemistryLuteolinApigeninXanthineTraditional medicineBotanyBiochemistryFlavonoid
MeSH terms
AnimalsCattleMilkPlant ExtractsXanthine Oxidase
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