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Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum.
Chemical and Pharmaceutical Bulletin · 1994 · Vol. 42(12) · pp. 2449–2451
Michihiro Kobayashi✉(Osaka University of Pharmaceutical Sciences)Shunji AokiKatsuhiko GatoK. MatsunamiMichio KurosuI Kitagawa
Abstract
A new antibiotic indole trimer named trisindoline (1) was isolated, together with a known dioxopiperazine brevianamide F (2), from the culture of a bacterium of Vibrio sp., which was separated from the Okinawan marine sponge Hyrtios altum. The structure of trisindoline (1) has been determined on the bases of physicochemical evidence and chemical synthesis.
Marine Sponges and Natural ProductsSynthesis and Biological ActivitySynthesis of Indole DerivativesTrimerSpongeChemistryIndole testBacteriaVibrioStereochemistryAntibioticsMarine bacteriophageMicrobiology
MeSH terms
AnimalsAnti-Bacterial AgentsBacteriaChromatography, High Pressure LiquidHydrolysisIndolesMagnetic Resonance SpectroscopyPoriferaVibrio
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