article Open AccessTop 1% cited
Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial
International Journal of Obesity · 2016 · Vol. 40(8) · pp. 1310–1319
on behalf of the SCALE study group✉(University of Toronto)Adam Blackman(University of Toronto)Gary D. Foster(Clinilabs (United States))Gary Zammit(Clinilabs (United States))Russell Rosenberg(Cornell University)Louis J. Aronne(Cornell University)Thomas A. Wadden(Novo Nordisk (Denmark))Birgitte Claudius(Novo Nordisk (Denmark))Camilla Jensen(Novo Nordisk (Denmark))Emmanuel Mignot(Stanford Medicine)
Abstract
As an adjunct to diet and exercise, liraglutide 3.0 mg was generally well tolerated and produced significantly greater reductions than placebo in AHI, body weight, SBP and HbA1c in participants with obesity and moderate/severe OSA. The results confirm that weight loss improves OSA-related parameters.
Obstructive Sleep Apnea ResearchRegulation of Appetite and ObesityDiabetes Treatment and ManagementMedicineObstructive sleep apneaLiraglutideSleep apneaRandomized controlled trialObesityApneaSleep (system call)Internal medicineEndocrinology
MeSH terms
LiraglutideAdolescentAdultDouble-Blind MethodFemaleGlycated HemoglobinHumansHypoglycemic AgentsMaleMiddle AgedObesityProspective StudiesUnited StatesWeight LossTreatment Outcome
Funding
- Novo Nordisk
Citations
506
FWCI
17.33
field-weighted impact
References
48
Percentile
100%
vs. same field & year
Citations per year
References
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
The Lancet · 2002 · 10,173 citations
An Instrument to Measure Functional Status Outcomes for Disorders of Excessive Sleepiness
SLEEP · 1997 · 882 citations
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
SLEEP · 1991 · 16,956 citations
Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
International Journal of Obesity · 2011 · 742 citations
Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: The SCALE Maintenance randomized study
International Journal of Obesity · 2013 · 812 citations
Excess weight and sleep-disordered breathing
Journal of Applied Physiology · 2005 · 829 citations
Increased Prevalence of Sleep-Disordered Breathing in Adults
American Journal of Epidemiology · 2013 · 4,531 citations
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
American Journal of Respiratory and Critical Care Medicine · 2002 · 4,206 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.