articleTop 1% cited
PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer
Gynecologic Oncology · 2016 · Vol. 141(2) · pp. 293–302
John R. Webb✉(University of Victoria)Katy Milne(BC Cancer Agency)David R. Kroeger(BC Cancer Agency)Brad H. Nelson(University of British Columbia)
Cancer Immunotherapy and BiomarkersImmune cells in cancerImmune Cell Function and InteractionCancer researchFOXP3Tissue microarrayOvarian cancerMedicineCD8Tumor-infiltrating lymphocytesGranzyme BImmune systemIL-2 receptor
MeSH terms
Carcinoma, Ovarian EpithelialFemaleHumansImmunohistochemistryMacrophagesNeoplasms, Glandular and EpithelialOvarian NeoplasmsPrognosisLymphocytes, Tumor-InfiltratingCystadenocarcinoma, SerousTissue Array AnalysisB7-H1 Antigen
Funding
- U.S. Department of Defense
- Health Canada
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- BC Cancer Agency
Citations
336
FWCI
18.75
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
References
Classifying Cancers Based on T-cell Infiltration and PD-L1
Cancer Research · 2015 · 1,441 citations
PD‐1 signaling in primary T cells
Immunological Reviews · 2009 · 762 citations
Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
Science Translational Medicine · 2012 · 2,123 citations
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
New England Journal of Medicine · 2012 · 7,941 citations
Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy
Clinical Cancer Research · 2014 · 2,320 citations
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies
PLoS Medicine · 2008 · 815 citations
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
The Journal of Experimental Medicine · 2014 · 2,102 citations
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