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A novel gene, <i>optrA</i>, that confers transferable resistance to oxazolidinones and phenicols and its presence in <i>Enterococcus faecalis</i> and <i>Enterococcus faecium</i> of human and animal origin
Journal of Antimicrobial Chemotherapy · 2015 · Vol. 70(8) · pp. 2182–2190
Yang Wang(China Agricultural University)Yuan Lv(Peking University)Jiachang Cai(Second Affiliated Hospital of Zhejiang University)Štefan Schwarz(Friedrich-Loeffler-Institut)Lanqing Cui(Peking University First Hospital)Zhidong Hu(Tianjin Medical University General Hospital)Rong Zhang(Second Affiliated Hospital of Zhejiang University)Jun Li(China Agricultural University)Qin Zhao(China Agricultural University)Tao He(China Agricultural University)Dacheng Wang(Jilin University)Zheng Wang(China Agricultural University)Yingbo Shen(China Agricultural University)Yun Li(Peking University)Andrea T. Feßler(Friedrich-Loeffler-Institut)Congming Wu(China Agricultural University)Hao Yu(Jilin University)Xuming Deng(Jilin University)Xi Xia(China Agricultural University)Jianzhong Shen✉(China Agricultural University)
Abstract
Enterococci with elevated MICs of linezolid and tedizolid should be tested not only for 23S rRNA mutations and the gene cfr, but also for the novel resistance gene optrA.
Antimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceEnterococcus faecalisEnterococcus faeciumEnterococcusMicrobiologyBiologyStreptococcaceaeGeneAntibacterial agentGeneticsAntibiotics
MeSH terms
AnimalsAnti-Bacterial AgentsChloramphenicolConjugation, GeneticDNA, BacterialGenes, BacterialHumansMicrobial Sensitivity TestsMolecular Sequence DataPhylogenyPlasmidsEnterococcus faecalisTransformation, BacterialCluster AnalysisGram-Positive Bacterial Infections
Funding
- National Natural Science Foundation of China
- National Key Research and Development Program of China
Citations
546
FWCI
23.11
field-weighted impact
References
30
Percentile
100%
vs. same field & year
Citations per year
References
The rise of the Enterococcus: beyond vancomycin resistance
Nature Reviews Microbiology · 2012 · 1,706 citations
Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus
FEMS Microbiology Letters · 1992 · 803 citations
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
Antimicrobial Agents and Chemotherapy · 2006 · 703 citations
Co-transfer of vancomycin and other resistance genes from<i>Enterococcus faecalis</i>NCTC 12201 to<i>Staphylococcus aureus</i>
FEMS Microbiology Letters · 1992 · 626 citations
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