review Open AccessTop 1% cited
PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs
Journal of Pharmaceutical Sciences · 2016 · Vol. 105(2) · pp. 460–475
Peter L. Turecek✉Mary J. Bossard(Nektar Therapeutics (United States))Freddy Schoetens(Janssen (United States))Inge A. Ivens(Bayer (United States))
Protein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical MethodsPEGylationPEG ratioPolyethylene glycolBiopharmaceuticalChemistryCombinatorial chemistryDrugPharmacologyNanotechnologyOrganic chemistry
MeSH terms
AnimalsBiopharmaceuticsChemistry, PharmaceuticalPharmaceutical PreparationsHumansPolyethylene GlycolsDrug ApprovalProtein StabilityDrug-Related Side Effects and Adverse Reactions
Citations
703
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References
154
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References
Chemistry for peptide and protein PEGylation
Advanced Drug Delivery Reviews · 2002 · 1,594 citations
The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics
Journal of Pharmaceutical Sciences · 2008 · 468 citations
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Angewandte Chemie International Edition · 2010 · 3,412 citations
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