review Open AccessTop 1% cited
Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
Metabolism · 2016 · Vol. 65(8) · pp. 1049–1061
Manoela Mota✉(Virginia Commonwealth University)Bubu A. Banini(Virginia Commonwealth University)Sophie C. Cazanave(Virginia Commonwealth University)Arun J. Sanyal✉(Virginia Commonwealth University)
Liver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and DiseaseDiet, Metabolism, and DiseaseLipotoxicityUnfolded protein responseLipogenesisDownregulation and upregulationEndocrinologyInternal medicineNonalcoholic fatty liver diseaseInsulin resistanceEndoplasmic reticulumOxidative stress
MeSH terms
HumansInsulin ResistanceMitochondriaSignal TransductionGlucose IntoleranceOxidative StressJNK Mitogen-Activated Protein KinasesTranscription Factor CHOPEndoplasmic Reticulum StressNon-alcoholic Fatty Liver Disease
Citations
560
FWCI
23.60
field-weighted impact
References
129
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100%
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A lipidomic analysis of nonalcoholic fatty liver disease
Hepatology · 2007 · 1,325 citations
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
American Journal of Physiology-Endocrinology and Metabolism · 2006 · 728 citations
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Endocrine Reviews · 2002 · 1,270 citations
Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2006 · 681 citations
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
Gastroenterology · 2001 · 2,066 citations
Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis
Cell Metabolism · 2015 · 989 citations
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