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The epidemiology of pituitary adenomas in Iceland, 1955–2012: a nationwide population-based study

European Journal of Endocrinology · 2015 · Vol. 173(5) · pp. 655–664

Tomas T. Agustsson✉(National University Hospital of Iceland)Tinna Baldvinsdottir(University of Iceland)Jón G. Jónasson(University of Iceland)Elínborg J. Ólafsdóttir(deCODE Genetics (Iceland))Valgerður Steinthórsdóttir(National University Hospital of Iceland)Gunnar Sigurðsson(University of Iceland)Árni V. Þórsson(University of Iceland)Paul Carroll(Guy's and St Thomas' NHS Foundation Trust)Márta Korbonits(Queen Mary University of London)Rafn Benediktsson(National University Hospital of Iceland)

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Abstract

In this nationwide study spanning six decades, we have confirmed PAs rising prevalence and incidence rates noted in recent studies. We demonstrated higher overall prevalence and incidence rates than ever previously recorded with an increasing predominance of NFPAs, which is not explained by incidental findings alone. There is a relationship with the introduction of imaging modalities, but the vast majority of patients are symptomatic at diagnosis. This underlines the importance of increased awareness, education, and appropriate allocation of resources for this growing group of patients.

Pituitary Gland Disorders and Treatments Adrenal and Paraganglionic Tumors Growth Hormone and Insulin-like Growth FactorsMedicineEpidemiologyIncidence (geometry)Pituitary adenomaAcromegalyPopulationAdenomaInternal medicineRetrospective cohort studyProlactinoma