Anti-inflammatory activity of characterized compound diosgenin isolated from Tinospora malabarica Miers in Ann. (Menispermaceae) in animal model.

Abstract

At concentrations of diosgenin isolated from Tinospora malabaricawas investigated in chemically-induced inflammation rodents’ model. It showed a significantly (P < 0.01) reduced mean paw edema volume at 3h after carrageenan injection. These extracts have exhibited anti-inflammatory activity in a dose-dependent manner with the per cent inhibition of paw edema, as compared with the control group. This result indicated that the characterized compound, diosgenin at the dose of 400µg/kg.b.wt showed a maximum anti-inflammatory activity of 82.25% as compared to the reference drug, indomethacin (82.01%). Therefore, our studies support the use of active constituents from T. malabarica in treating inflammations.