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Revisiting Cardiac Cellular Composition
Circulation Research · 2016 · Vol. 118(3) · pp. 400–409
Alexander R. Pinto✉(Australian Regenerative Medicine Institute)Alexei Ilinykh(Monash University)Malina J. Ivey(Imperial College London)Jill T. Kuwabara(Monash University)Michelle L. D’Antoni(Imperial College London)Ryan J. Debuque(Australian Regenerative Medicine Institute)Anjana Chandran(Australian Regenerative Medicine Institute)Lina Wang(Australian Regenerative Medicine Institute)Komal Arora(Imperial College London)Nadia Rosenthal(Monash University)Michelle D. Tallquist(Australian Regenerative Medicine Institute)
Abstract
This new perspective on the abundance of different cell types in the heart demonstrates that fibroblasts comprise a relatively minor population. By contrast, endothelial cells constitute the majority of noncardiomyocytes and are likely to play a greater role in physiological function and response to injury than previously appreciated.
Cardiac Fibrosis and RemodelingAdipose Tissue and MetabolismCardiovascular Function and Risk FactorsComposition (language)BiologyChemistry
MeSH terms
AdultAnimalsCell CountCell DifferentiationCell SeparationFemaleFibroblastsFlow CytometryGene Expression RegulationHeartHematopoietic Stem CellsHumansImmunohistochemistryMaleMice, Inbred C57BL
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