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Revisiting Cardiac Cellular Composition

Circulation Research · 2016 · Vol. 118(3) · pp. 400–409
Alexander R. PintoAlexei IlinykhMalina J. IveyJill T. KuwabaraMichelle L. D’AntoniRyan J. DebuqueAnjana ChandranLina WangKomal AroraNadia RosenthalMichelle D. Tallquist

Abstract

This new perspective on the abundance of different cell types in the heart demonstrates that fibroblasts comprise a relatively minor population. By contrast, endothelial cells constitute the majority of noncardiomyocytes and are likely to play a greater role in physiological function and response to injury than previously appreciated.

MeSH terms

AdultAnimalsCell CountCell DifferentiationCell SeparationFemaleFibroblastsFlow CytometryGene Expression RegulationHeartHematopoietic Stem CellsHumansImmunohistochemistryMaleMice, Inbred C57BL
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References
The Many Faces of Endothelial Microparticles
Arteriosclerosis Thrombosis and Vascular Biology · 2010 · 616 citations
Cardiomyocyte DNA synthesis and binucleation during murine development
American Journal of Physiology-Heart and Circulatory Physiology · 1996 · 724 citations
Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse
American Journal of Physiology-Heart and Circulatory Physiology · 2007 · 624 citations
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