article Open AccessTop 10% cited

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 16(1) · pp. 31–35

Patricia Melnyk✉(Centre National de la Recherche Scientifique)Vincent Leroux(Centre National de la Recherche Scientifique)Christian Sergheraert(Université de Lille)Philippe Grellier

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Malaria Research and Control Drug-Induced Hepatotoxicity and Protection Mosquito-borne diseases and controlChemistryPlasmodium falciparumIn vitroChloroquineChelationDeferoxamineCombinatorial chemistryPharmacologyChemical synthesisMalaria

MeSH terms

AnimalsAntimalarialsChelating AgentsChemistry, PharmaceuticalDeferoxamineDrug ResistanceEnzyme InhibitorsHumansHydrazonesIronModels, ChemicalPlasmodium falciparumTechnology, PharmaceuticalDrug DesignInhibitory Concentration 50

Funding

Université de Lille

Citations

251

FWCI

5.38

field-weighted impact

References

Percentile

95%

vs. same field & year

Citations per year

References

Human Malaria Parasites in Continuous Culture

Science · 1976 · 7,934 citations

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

Antimicrobial Agents and Chemotherapy · 1979 · 2,501 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Journal of Immunological Methods · 1983 · 55,054 citations

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