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Intracellular Protein Degradation in Mammalian and Bacterial Cells

Annual Review of Biochemistry · 1974 · Vol. 43(1) · pp. 835–869

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

Biotechnology and Related FieldsDrosophila melanogasterCell biologyRegulatorIntracellularCell fate determinationBiologySignal transductionCell growthHippo signaling pathwayChemistry

MeSH terms

Amino AcidsBacterial ProteinsCarbon RadioisotopesChymotrypsinElectrophoresisEscherichia coliHalf-LifeIsotope LabelingKineticsLevulinic AcidsLiverMutationPeptide HydrolasesProteinsRNA, Bacterial

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Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC