article Open AccessTop 10% cited

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Bioorganic & Medicinal Chemistry Letters · 2004 · Vol. 14(24) · pp. 6083–6087

Justin J. J. Leahy(Newcastle University)Bernard T. Golding(Newcastle University)Roger J. Griffin✉(Newcastle University)Ian R. Hardcastle(Newcastle University)Caroline J. Richardson(GW Pharmaceuticals (United Kingdom))Laurent Rigoreau(GW Pharmaceuticals (United Kingdom))Graeme C.M. Smith(GW Pharmaceuticals (United Kingdom))

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DNA and Nucleic Acid Chemistry Cancer therapeutics and mechanisms Bioactive Compounds and Antitumor AgentsChemistryDNAEnzymeKineticsKinaseProtein kinase ABiochemistryNon-competitive inhibitionEnzyme inhibitorCombinatorial chemistry

MeSH terms

ChromonesDNA-Binding ProteinsEnzyme InhibitorsMorpholinesStructure-Activity RelationshipMolecular StructureProtein Serine-Threonine KinasesDNA-Activated Protein Kinase

Funding

Cancer Research UK

Citations

404

FWCI

3.12

field-weighted impact

References

Percentile

92%

vs. same field & year

Citations per year

References

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Journal of Biological Chemistry · 1994 · 3,250 citations

Sensing and repairing DNA double-strand breaks

Carcinogenesis · 2002 · 1,130 citations

Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998

Journal of Organometallic Chemistry · 1999 · 2,894 citations

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