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Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors
Bioorganic & Medicinal Chemistry Letters · 2003 · Vol. 13(4) · pp. 657–660
R. Paramashivappa(Vittal Mallya Scientific Research Foundation)P. Phani Kumar(Vittal Mallya Scientific Research Foundation)P. Sriramarao(Vittal Mallya Scientific Research Foundation)A. Srinivasa Rao✉(Vittal Mallya Scientific Research Foundation)
Inflammatory mediators and NSAID effectsSynthesis and biological activityComputational Drug Discovery MethodsBenzothiazoleChemistryBenzoxazoleCyclooxygenaseThio-BenzimidazoleEnzyme inhibitorEnzymeStereochemistryBiological activity
MeSH terms
BenzimidazolesBenzoxazolesBloodDrug Evaluation, PreclinicalHeterocyclic CompoundsHumansIsoenzymesMembrane ProteinsProstaglandin-Endoperoxide SynthasesStructure-Activity RelationshipThiazolesCyclooxygenase InhibitorsInhibitory Concentration 50Cyclooxygenase 1Cyclooxygenase 2
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