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The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response
Annual Review of Immunology · 1989 · Vol. 7(1) · pp. 625–655
Bruce Beutler✉(Howard Hughes Medical Institute)Anthony Cerami
Abstract
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Public Health and NutritionBiologyEffectorMediatorTumor necrosis factor alphaImmunologyCell biologyCD8Lineage (genetic)ReceptorImmune system
MeSH terms
AnimalsGene Expression RegulationLymphotoxin-alphaRabbitsReceptors, Cell SurfaceTumor Necrosis Factor-alphaReceptors, Tumor Necrosis Factor
Funding
- National Institutes of Health
Citations
1,687
FWCI
164.47
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