articleTop 1% cited
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
Science Translational Medicine · 2015 · Vol. 7(315)
Jeffrey A. Bluestone✉(University of California, San Francisco)Jane H. Buckner(Benaroya Research Institute)Mark Fitch(University of California, Berkeley)Stephen E. Gitelman(University of California, San Francisco)Shipra Gupta(Benaroya Research Institute)Marc K. Hellerstein(University of California, Berkeley)Kevan C. Herold(Yale University)Angela Lares(University of California, San Francisco)Michael R. F. Lee(University of California, San Francisco)Kelvin Li(KineMed (United States))Weihong Liu(University of California, San Francisco)S. Alice Long(Benaroya Research Institute)Lisa M. Masiello(University of California, San Francisco)Vinh Nguyen(University of California, San Francisco)Amy Putnam(University of California, San Francisco)Mary Rieck(University of California, San Francisco)Peter H. SayreQizhi Tang(University of California, San Francisco)
Abstract
Autologous regulatory T cells can be expanded and are well tolerated in patients with recent-onset type 1 diabetes.
Diabetes and associated disordersImmune Cell Function and InteractionPancreatic function and diabetesImmunotherapyPolyclonal antibodiesType 2 diabetesDiabetes mellitusMedicineType 1 diabetesRegulatory T cellImmunologyCancer researchImmune system
Funding
- Juvenile Diabetes Research Foundation International
- BD Biosciences
Citations
999
FWCI
57.56
field-weighted impact
References
44
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100%
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References
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
DNA demethylation in the human <i>FOXP3</i> locus discriminates regulatory T cells from activated FOXP3<sup>+</sup> conventional T cells
European Journal of Immunology · 2007 · 673 citations
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
The Journal of Experimental Medicine · 2006 · 2,571 citations
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
The Journal of Immunology · 1995 · 5,432 citations
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