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Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy
Annual Review of Immunology · 1989 · Vol. 7(1) · pp. 445–480
Daniel L. Mueller✉(National Institute of Allergy and Infectious Diseases)Marc K. JenkinsR H Schwartz
Abstract
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
T-cell and B-cell ImmunologyImmune Cell Function and InteractionCAR-T cell therapy researchBiologyEffectorSignallingCD8ImmunologyReceptorAntigenCell biologyLineage (genetic)T-cell receptor
MeSH terms
Antigen-Presenting CellsGene Expression RegulationHumansLymphocyte ActivationModels, BiologicalReceptors, Antigen, T-Cell
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