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AMP-activated protein kinase, super metabolic regulator
Biochemical Society Transactions · 2003 · Vol. 31(1) · pp. 162–168
Bruce E. Kemp✉(St Vincents Institute of Medical Research)David Stapleton(St Vincents Institute of Medical Research)Duncan J. Campbell(St Vincents Institute of Medical Research)Z.-P. Chen(University of Melbourne)Sid Murthy(St Vincents Institute of Medical Research)Mark Walter(University of Melbourne)Abhilasha Gupta(St Vincents Institute of Medical Research)Julian J. Adams(University of Melbourne)Frosa Katsis(University of Melbourne)Bryce van Denderen(University of Melbourne)Ian G. Jennings(St Vincents Institute of Medical Research)Tristan J. Iseli(University of Melbourne)Belinda J. Michell(St Vincents Institute of Medical Research)Lee A. Witters
Abstract
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
Metabolism, Diabetes, and CancerNatural Antidiabetic Agents StudiesAMPKAMP-activated protein kinaseProtein kinase ARegulatorASK1Cell biologyKinaseChemistryMitogen-activated protein kinase kinaseLimiting
MeSH terms
AnimalsDiabetes MellitusGene Expression RegulationGlucoseGlycolysisHumansLipidsModels, BiologicalModels, MolecularMultienzyme ComplexesMutationObesityPhosphorylationProtein Serine-Threonine KinasesProtein Structure, Tertiary
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