article Open AccessTop 10% cited
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
BMC Genomics · 2011 · Vol. 12(1) · pp. 14–14
Brady K. Atwood✉(Indiana University Bloomington)Jacqueline Lopez(Indiana University Bloomington)James Wager‐Miller(Indiana University Bloomington)Ken Mackie(Indiana University Bloomington)Alex Straiker(Indiana University Bloomington)
Abstract
This study provides researchers an easily accessible mRNA profile of the endogenous signaling repertoire that these four cell lines possess. This will assist in choosing the most appropriate cell line for studying GPCRs and related signaling proteins. It also provides a better understanding of the potential interactions between GPCRs and those signaling proteins.
Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingViral Infectious Diseases and Gene Expression in InsectsG protein-coupled receptorBiologyComputational biologyHEK 293 cellsMicroarrayReceptorSignal transductionProteomicsBioinformaticsGene expression
MeSH terms
AnimalsCell LineHumansRNA, MessengerGene ExpressionOligonucleotide Array Sequence AnalysisReceptors, G-Protein-CoupledMice
Funding
- Eli Lilly and Company
- Lilly Endowment
- National Institutes of Health
- National Center for Research Resources
Citations
425
FWCI
7.05
field-weighted impact
References
78
Percentile
98%
vs. same field & year
Citations per year
References
Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
The FASEB Journal · 2002 · 781 citations
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