articleTop 1% cited

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Nature Medicine · 2007 · Vol. 13(6) · pp. 688–694

Ikuroh Ohsawa✉(Nippon Medical School)Masahiro Ishikawa(Nippon Medical School)Kumiko Takahashi(Nippon Medical School)Megumi Watanabe(Nippon Medical School)Kiyomi Nishimaki(Nippon Medical School)Kumi Yamagata(Nippon Medical School)Ken‐ichiro Katsura(Nippon Medical School)Yasuo Katayama(Nippon Medical School)Sadamitsu Asoh(Nippon Medical School)Shigeo Ohta(Nippon Medical School)

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Hydrogen's biological and therapeutic effects Sulfur Compounds in Biology Anesthesia and Neurotoxicity ResearchOxidative stressReactive oxygen speciesAntioxidantChemistryOxidative phosphorylationIschemiaCytotoxic T cellInflammationPharmacologyRadical

MeSH terms

Administration, InhalationAnimalsAntioxidantsCerebral InfarctionDisease Models, AnimalHumansHydrogenMaleOxidation-ReductionReperfusion InjuryPC12 CellsRats, Sprague-DawleyHydroxyl RadicalRatsMembrane Potential, Mitochondrial

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Ischemia and reperfusion—from mechanism to translation