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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Nature Medicine · 2012 · Vol. 18(6) · pp. 883–891

Héctor Peinado(Children's Cancer and Blood Foundation)Maša Alečković(Princeton University)Simon Lavotshkin(Columbia University)Irina Matei(Cornell University)Bruno Costa‐Silva(AC Camargo Hospital)Gema Moreno‐Bueno(Instituto de Investigaciones Biomédicas Sols-Morreale)Marta Hergueta‐Redondo(Instituto de Investigaciones Biomédicas Sols-Morreale)Caitlin Williams(Cornell University)Guillermo García‐Santos(Cornell University)Cyrus M. Ghajar(Lawrence Berkeley National Laboratory)Ayuko Nitadori-Hoshino(Children's Cancer and Blood Foundation)Caitlin Hoffman(Cornell University)Karen Badal(Children's Cancer and Blood Foundation)Benjamin A. Garcia(Princeton University)Margaret K. Callahan(Memorial Sloan Kettering Cancer Center)Jianda Yuan(Kettering University)Vilma R. Martins(Hospital São Paulo)Johan Skog(Exosome Diagnostics (United States))Rosandra N. Kaplan(National Cancer Institute)Mary S. Brady(Memorial Sloan Kettering Cancer Center)Jedd D. Wolchok(Memorial Sloan Kettering Cancer Center)Paul B. Chapman(Cornell University)Yibin Kang(Princeton University)Jacqueline Bromberg(Memorial Sloan Kettering Cancer Center)David Lyden✉(Children's Cancer and Blood Foundation)

View via DOI Publisher page

Extracellular vesicles in disease MicroRNA in disease regulation Circular RNAs in diseasesMicrovesiclesExosomeCancer researchBone marrowProgenitor cellMetastasisReceptor tyrosine kinaseMelanomaMedicineStem cell

MeSH terms

rab27 GTP-Binding ProteinsAnimalsBone Marrow CellsCell LineFemaleHumansMelanomaMice, Inbred C57BLPhenotypePrognosisStem CellsProto-Oncogene Proteins c-metrab GTP-Binding ProteinsMiceExosomes

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The biology and function of exosomes in cancer