review Open AccessTop 1% cited

Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis

Archives of Disease in Childhood · 2008 · Vol. 93(6) · pp. 512–517

Christos Zipitis✉(Stockport NHS Foundation Trust)Anthony K Akobeng(Royal Manchester Children's Hospital)

Abstract

Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.

Vitamin D Research Studies Diabetes and associated disorders Obesity, Physical Activity, DietMedicineObservational studyType 2 diabetesMeta-analysisCohort studyDiabetes mellitusOdds ratioRandomized controlled trialPediatricsType 1 diabetes

MeSH terms

AdolescentAge FactorsChildChild, PreschoolDiabetes Mellitus, Type 1Dose-Response Relationship, DrugHumansInfantVitamin DVitamin D DeficiencyVitaminsCase-Control Studies

Citations

657

FWCI

38.58

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Vitamin D: Nutrient, Hormone, and Immunomodulator