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The scanning model for translation: an update.
The Journal of Cell Biology · 1989 · Vol. 108(2) · pp. 229–241
M Kozak✉(University of Pittsburgh)
Abstract
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.
RNA and protein synthesis mechanismsRNA Research and SplicingViral Infections and Immunology ResearchBiologyTranslation (biology)RibosomeContext (archaeology)Messenger RNAProtein subunitCell biologyComputational biologyRNAGenetics
MeSH terms
AnimalsCodonGenes, FungalGenes, ViralHumansModels, BiologicalRegulatory Sequences, Nucleic AcidRibosomesRNA, MessengerRNA, Transfer, Amino AcylProtein Biosynthesis
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