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PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells

Cardiovascular Research · 2005 · Vol. 66(3) · pp. 562–573

Inmaculada Valle✉(Consejo Superior de Investigaciones Científicas)Alberto Álvarez(Instituto de Salud Carlos III)Elvira Arza(Instituto de Salud Carlos III)Santiago Lamas(Instituto de Salud Carlos III)Marı́a Monsalve(Centro de Investigaciones Biológicas Margarita Salas)

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Abstract

These results unveil a novel regulatory pathway that links mitochondrial activity and mitochondrial oxidative stress protective systems. In addition, they suggest that PGC-1alpha could play a crucial protective role in vascular complications of diabetes, where the mitochondrial metabolism of glucose has been shown to result in oxidative stress and vascular endothelial cell dysfunction.

Adipose Tissue and Metabolism Mitochondrial Function and Pathology Peroxisome Proliferator-Activated ReceptorsMitochondrial biogenesisOxidative stressCell biologyMitochondrionBiologyMitochondrial ROSReactive oxygen speciesDownregulation and upregulationEndothelial stem cellBiochemistry

MeSH terms

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsCattleCells, CulturedFlow CytometryGene Expression RegulationGlucoseHeat-Shock ProteinsHumansMice, Inbred C57BLMitochondriaMuscle, Smooth, VascularTranscription FactorsApoptosisReactive Oxygen Species