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Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites

Journal of Pharmacology and Experimental Therapeutics · 1997 · Vol. 283(3) · pp. 1305–1322

Michael J. Owens✉W. Neal Morgan(Emory University)Susan J. Plott(Emory University)Charles B. Nemeroff(Emory University)

Receptor Mechanisms and Signaling Neurotransmitter Receptor Influence on Behavior Neuroscience and Neuropharmacology ResearchPharmacologySerotonergicSerotoninMuscarinic acetylcholine receptorChemistryReceptorSerotonin transporterSerotonin Plasma Membrane Transport ProteinsRadioligandNorepinephrine transporter

MeSH terms

AnimalsCarrier ProteinsChromatography, High Pressure LiquidGuinea PigsHumansMaleMembrane GlycoproteinsNerve Tissue ProteinsPiperazinesRadioligand AssayReceptors, SerotoninTriazolesRats, Sprague-DawleyReceptors, NeurotransmitterAntidepressive Agents, Second-Generation

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Antidepressants and Sleep