articleTop 1% cited

Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine Dimethylaminohydrolase

Arteriosclerosis Thrombosis and Vascular Biology · 2003 · Vol. 23(8) · pp. 1455–1459

Vinod Achan✉(British Heart Foundation)Michael Broadhead(British Heart Foundation)Mohammed Malaki(British Heart Foundation)Guy Whitley(British Heart Foundation)James Leiper(British Heart Foundation)Raymond J. MacAllister(British Heart Foundation)Patrick Vallance(British Heart Foundation)

View via DOI Publisher page

Abstract

This study defines the cardiovascular effects of a systemic increase in ADMA in humans. These are similar to changes seen in diseases associated with ADMA accumulation. Finally, our data also indicate that ADMA is metabolized by DDAHs extensively in humans in vivo.

Nitric Oxide and Endothelin Effects Renin-Angiotensin System Studies Cardiovascular Issues in PregnancyAsymmetric dimethylarginineInternal medicineHeart failureMedicineEndocrinologyBlood pressureHeart rateNitric oxide synthaseVascular resistanceCardiac output

MeSH terms

AdultAmidohydrolasesArginineBlood PressureCardiac OutputDouble-Blind MethodHeart RateHumansHypertensionInjections, IntravenousMaleVascular Resistance

Funding

British Heart Foundation

Citations

592

FWCI

17.23

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Nitric oxide deficiency in chronic kidney disease

American Journal of Physiology-Renal Physiology · 2007 · 410 citations

References

Determination of serum creatinine by a direct colorimetric method

Clinica Chimica Acta · 1973 · 719 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.