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Systematic Pelvic Lymphadenectomy vs No Lymphadenectomy in Early-Stage Endometrial Carcinoma: Randomized Clinical Trial

JNCI Journal of the National Cancer Institute · 2008 · Vol. 100(23) · pp. 1707–1716

Pierluigi Benedetti Panici✉(Sapienza University of Rome)S. Basile(Sapienza University of Rome)F. Maneschi(Ospedale Santa Maria Goretti)Andrea Alberto Lissoni(Azienda Ospedaliera San Gerardo)Mauro Signorelli(Azienda Ospedaliera San Gerardo)Giovanni Scambia(Agostino Gemelli University Polyclinic)Roberto AngioliSaverio Tateo(Policlinico San Matteo Fondazione)Giorgia Mangili(Vita-Salute San Raffaele University)Dionyssios Katsaros(St. Anna Hospital)G Garozzo(University of Catania)E CampagnuttaNicoletta Donadello(Fondazione Audiologica Varese)Stefano Greggi(Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale")Mauro Melpignano(University of Parma)Francesco RaspagliesiNicola Ragni(University of Genoa)Gennaro Cormio(University of Bari Aldo Moro)Roberto Grassi(Azienda Ospedaliera Treviglio)Massimo Piergiuseppe Franchi(University of Verona)Diana Giannarelli(Tumori Foundation)Roldano Fossati(Mario Negri Institute for Pharmacological Research)Valter Torri(Mario Negri Institute for Pharmacological Research)M. Amoroso(Sapienza University of Rome)C. Della Croce(University of Miami)Costantino Mangioni(Azienda Ospedaliera San Gerardo)

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Abstract

Although systematic pelvic lymphadenectomy statistically significantly improved surgical staging, it did not improve disease-free or overall survival.

Endometrial and Cervical Cancer Treatments Ovarian cancer diagnosis and treatment Uterine Myomas and TreatmentsMedicineLymphadenectomyEndometrial cancerInterquartile rangeLymph nodeCarcinomaStage (stratigraphy)SurgeryRandomized controlled trialPelvis

MeSH terms

Adenocarcinoma, PapillaryAgedCarcinoma, Squamous CellFemaleHumansHysterectomyLymph Node ExcisionMiddle AgedNeoplasm StagingOvariectomyPredictive Value of TestsPrognosisProspective StudiesResearch DesignProportional Hazards Models

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1,541

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100%

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Cited by

Endometrial cancer: A review and current management strategies: Part I