articleTop 1% cited

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Journal of Pharmacology and Experimental Therapeutics · 2013 · Vol. 344(3) · pp. 708–717

Scott M. DeWire✉(CSL (United States))Dennis S. YamashitaDavid H. RomingerGuodong LiuConrad L. CowanThomas M. GraczykXiaotao ChenPhilip PitisDimitar B. GotchevCatherine YuanMichael KoblishMichael W. LarkJonathan D. Violin

View via DOI Publisher page

Receptor Mechanisms and Signaling Neuropeptides and Animal Physiology Pharmacological Receptor Mechanisms and EffectsMorphineAnalgesicOpioidμ-opioid receptorRespiratory systemPharmacologyReceptorMedicineG protein-coupled receptorOpioid receptor

MeSH terms

beta-Arrestinsbeta-Arrestin 2AnalgesicsAnimalsCell LineGastrointestinal DiseasesHumansLigandsMaleMice, Inbred C57BLMorphineRespiratory SystemRespiratory Tract DiseasesSignal TransductionRats, Sprague-Dawley

Funding

National Institutes of Health

Citations

639

FWCI

17.04

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

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References

The kinetics of competitive radioligand binding predicted by the law of mass action.

Molecular Pharmacology · 1984 · 418 citations

β-Arrestin-biased ligands at seven-transmembrane receptors

Trends in Pharmacological Sciences · 2007 · 587 citations

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Journal of Pharmacology and Experimental Therapeutics · 2005 · 601 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

Journal of Pharmacology and Experimental Therapeutics · 1941 · 3,222 citations

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