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Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>Mutations

Clinical Cancer Research · 2012 · Vol. 18(2) · pp. 400–407

Min-Han Tan(Cleveland Clinic Lerner College of Medicine)Jessica L. Mester(Case Western Reserve University)Joanne Ngeow(Cleveland Clinic Lerner College of Medicine)Lisa Rybicki(Cleveland Clinic Lerner College of Medicine)Mohammed S. Orloff(Case Western Reserve University)Charis Eng✉(Cleveland Clinic Lerner College of Medicine)

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Abstract

Lifetime risks for a variety of cancers, now extending to colorectal cancer, kidney cancer, and melanoma, are increased in patients with PTEN mutations. The genotype-phenotype associations here may provide new insights on PTEN structure and function. We propose a comprehensive approach to surveillance of patients with PTEN mutations.

PI3K/AKT/mTOR signaling in cancer BRCA gene mutations in cancer Genetic factors in colorectal cancerPTENCowden syndromeMedicineCancerOncologyBreast cancerGermline mutationThyroid cancerPenetranceColorectal cancer

MeSH terms

Breast NeoplasmsFemaleHamartoma Syndrome, MultipleHumansKidney NeoplasmsProspective StudiesRisk FactorsThyroid NeoplasmsColorectal NeoplasmsIncidenceEndometrial NeoplasmsGerm-Line MutationCodon, NonsensePenetranceMutation, Missense