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Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders
Archives of Disease in Childhood · 2001 · Vol. 85(5) · pp. 421–426
Sujata Sawhney✉(Great Ormond Street Hospital)
Abstract
MAS is a rare and potentially fatal complication of childhood rheumatic disorders. Most of our patients were female, and most cases were preceded by infection. Bone marrow studies support the diagnosis. Deranged renal function may be a poor prognostic sign. Aggressive early therapy is essential.
Autoimmune and Inflammatory Disorders ResearchParvovirus B19 Infection StudiesInflammasome and immune disordersMedicineMacrophage activation syndromeHepatosplenomegalyComplicationErythrocyte sedimentation rateArthritisCoagulopathyInternal medicineSurgeryCyclophosphamide
MeSH terms
AdolescentArthritis, JuvenileChildChild, PreschoolFemaleGlucocorticoidsHumansImmune System DiseasesInfantInfectionsMacrophage ActivationMalePrognosisRetrospective StudiesRisk Factors
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References
Virus-associated hemophagocytic syndromeA benign histiocytic proliferation distinct from malignant histiocytosis
Cancer · 1979 · 1,067 citations
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