articleTop 1% cited

Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis

Journal of Pharmacology and Experimental Therapeutics · 2014 · Vol. 349(2) · pp. 209–220

Lutz Wollin✉(Boehringer Ingelheim (Germany))Isabelle Maillet(Centre National de la Recherche Scientifique)Valérie Quesniaux(Boehringer Ingelheim (Germany))Alexander Holweg(Centre National de la Recherche Scientifique)Bernhard Ryffel(Boehringer Ingelheim (Germany))

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Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Peptidase Inhibition and Analysis Eosinophilic Disorders and SyndromesNintedanibPlatelet-derived growth factor receptorPulmonary fibrosisFibrosisBleomycinIdiopathic pulmonary fibrosisBronchoalveolar lavageMedicineMyofibroblastCancer research

MeSH terms

AnimalsAnti-Inflammatory AgentsBleomycinCell DifferentiationFibroblastsFibrosisGranulomaHumansIndolesLungMice, Inbred C57BLPhosphorylationPneumoniaProtein-Tyrosine KinasesSilicon Dioxide

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Idiopathic Pulmonary Fibrosis (IPF): An Overview