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Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival

JNCI Journal of the National Cancer Institute · 2000 · Vol. 92(12) · pp. 994–1000

Sandra E. Sephton✉(University of Louisville)

Abstract

Patients with metastatic breast cancer whose diurnal cortisol rhythms were flattened or abnormal had earlier mortality. Suppression of NK cell count and NK function may be a mediator or a marker of more rapid disease progression.

Tryptophan and brain disorders Stress Responses and Cortisol Cancer-related cognitive impairment studiesCircadian rhythmProportional hazards modelBreast cancerMedicineInternal medicineEndocrinologyDiurnal temperature variationCancerHydrocortisoneOncology

MeSH terms

AdultBreast NeoplasmsCircadian RhythmFemaleHumansHydrocortisoneIodine RadioisotopesKiller Cells, NaturalMiddle AgedPredictive Value of TestsPrognosisRadioimmunoassaySalivaSocial SupportProportional Hazards Models

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