article Open AccessTop 10% cited
Pharmacokinetic and pharmacodynamic properties of oral L‐citrulline and L‐arginine: impact on nitric oxide metabolism
British Journal of Clinical Pharmacology · 2007 · Vol. 65(1) · pp. 51–59
Edzard Schwedhelm✉(Universität Hamburg)Renke Maas(University Medical Center Hamburg-Eppendorf)Ralf FreeseDonald Jung(West Pharmaceutical Services (United Kingdom))Zoltán Lukács(University Medical Center Hamburg-Eppendorf)Alen JambrecinaWilliam SpicklerFriedrich Schulze(Universität Hamburg)Rainer H. Böger(University Medical Center Hamburg-Eppendorf)
Abstract
Our data show for the first time that oral L-citrulline supplementation raises plasma L-arginine concentration and augments NO-dependent signalling in a dose-dependent manner.
Nitric Oxide and Endothelin EffectsBlood Pressure and Hypertension StudiesCardiovascular Syncope and Autonomic DisordersAsymmetric dimethylarginineArginineCitrullinePharmacokineticsPharmacodynamicsNitric oxideInternal medicinePharmacologyEndocrinologyVasodilation
MeSH terms
Administration, OralArginineCitrullineDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedNitric OxidePlacebosVasodilationCross-Over StudiesNitric Oxide Synthase
Citations
493
FWCI
4.11
field-weighted impact
References
43
Percentile
94%
vs. same field & year
Citations per year
Cited by
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References
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery
Journal of the American College of Cardiology · 2002 · 4,564 citations
Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns
Clinical Chemistry · 2003 · 619 citations
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