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Strontium Ranelate Reduces the Risk of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) Study

The Journal of Clinical Endocrinology & Metabolism · 2005 · Vol. 90(5) · pp. 2816–2822

Jean‐Yves Reginster✉(University of Liège)Ego Seeman(University of Melbourne)M.C. de Vernejoul(Hôpital Lariboisière)S. AdámiJuliet Compston(University of Cambridge)C. Phenekos(Red Cross Hospital)J.-P. Devogelaer(UCLouvain)Díaz Curiel M(Hospital Universitario Fundación Jiménez Díaz)Adam SawickiStefan Goemaere(Ghent University Hospital)O. H. Sørensen(Hvidovre Hospital)Dieter Felsenberg(Freie Universität Berlin)Pierre J. Meunier(Hôpital Edouard Herriot)

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Abstract

This study shows that strontium ranelate significantly reduces the risk of all nonvertebral and in a high-risk subgroup, hip fractures over a 3-yr period, and is well tolerated. It confirms that strontium ranelate reduces vertebral fractures. Strontium ranelate offers a safe and effective means of reducing the risk of fracture associated with osteoporosis.

Bone health and osteoporosis research Bone Metabolism and Diseases Bone health and treatmentsStrontium ranelateOsteoporosisMedicinePostmenopausal osteoporosisPeripheralInternal medicineBone mineral

MeSH terms

AgedAged, 80 and overDouble-Blind MethodFemaleHumansOrganometallic CompoundsThiophenesBone DensityOsteoporosis, PostmenopausalSpinal FracturesFractures, Bone

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1,065

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74.96

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Incidence and Economic Burden of Osteoporosis-Related Fractures in the United States, 2005–2025