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Randomized Multicenter Trial of Sentinel Node Biopsy Versus Standard Axillary Treatment in Operable Breast Cancer: The ALMANAC Trial
JNCI Journal of the National Cancer Institute · 2006 · Vol. 98(9) · pp. 599–609
Robert E. Mansel✉(Cardiff University)Lesley Fallowfield(Queen Elizabeth Hospital Birmingham)Mark Kissin(Leeds General Infirmary)Amit Goyal(Royal Derby Hospital)Robert G. Newcombe(Western General Hospital)J. Michael Dixon(North Middlesex Hospital)Constantinos Yiangou(Brighton and Sussex Medical School)Kieran Horgan(Royal Derby Hospital)Nigel Bundred(Brighton and Sussex Medical School)Ian Monypenny(Royal Derby Hospital)David England(Cancer Research UK)Mark Sibbering(Cancer Research UK)Tholkifl I. Abdullah(Peterborough City Hospital)Lester Barr(Peterborough City Hospital)U Chetty(Royal Derby Hospital)Dudley H. Sinnett(Brighton and Sussex Medical School)Anne Fleissig(Brighton and Sussex Medical School)Dayalan Clarke(Royal Derby Hospital)Peter J. Ell(Charing Cross Hospital)
Abstract
Sentinel lymph node biopsy is associated with reduced arm morbidity and better quality of life than standard axillary treatment and should be the treatment of choice for patients who have early-stage breast cancer with clinically negative nodes.
Breast Cancer Treatment StudiesBreast Lesions and CarcinomasBreast Implant and ReconstructionMedicineSentinel nodeRandomized controlled trialBreast cancerMulticenter trialBiopsyOncologyInternal medicineCancerMulticenter study
MeSH terms
ArmAxillaBreast NeoplasmsDrainageFemaleHumansLength of StayLymph Node ExcisionLymphatic MetastasisLymphedemaMaleMastectomyMiddle AgedMovementQuality of Life
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References
Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer
Breast Cancer Research and Treatment · 2005 · 493 citations
Probable Inference, the Law of Succession, and Statistical Inference
Journal of the American Statistical Association · 1927 · 3,590 citations
Factors affecting failed localisation and false-negative rates of sentinel node biopsy in breast cancer – results of the ALMANAC validation phase
Breast Cancer Research and Treatment · 2006 · 328 citations
Interval estimation for the difference between independent proportions: comparison of eleven methods
Statistics in Medicine · 1998 · 1,831 citations
American Society of Clinical Oncology Guideline Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer
Journal of Clinical Oncology · 2005 · 1,885 citations
Comparative analysis of two rates
Statistics in Medicine · 1985 · 1,095 citations
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